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lipomatosis
Epidemiology: rare
Genetics:
- autosomal dominant
- genetic aberration in HMGA2
- chromosomal translocation t(3;12)(q27-q28;q13-q15) involving HMGA2 with LPP is associated with lipomatosis
Pathology:
- benign condition
Clinical manifestations:
- multiple encapsulated lipomas form on the trunk & extremities, with relatively few on the head & shoulders [1]
Differential diagnosis:
- other entities are associated with multiple lipomas
- Proteus syndrome
- Cowden syndrome
- disorders due to PTEN gene mutations,
- benign symmetric lipomatosis (Madelung disease)
- familial lipodystrophy
- hibernomas
- familial angiolipomatosis
Management:
- cosmetic: excision vs liposuction
General
lipid disorder (dyslipidemia)
skin disease (dermatologic disorder, dermatopathy, dermatosis)
References
- Wikipedia: Lipomatosis
http://en.wikipedia.org/wiki/Lipomatosis
- Soft Tissue Tumors: Adipose tissue: Lipomatosis
http://www.pathologyoutlines.com/topic/softtissueadiposelipomatosis.html