Search
phosphatidate phosphatase LPIN3; lipin-3; lipin-3-like (LPIN3, LIPN3L)
Function:
- regulates fatty acid metabolism
- Mg+2-dependent phosphatidate phosphatase
- catalyzes conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine & phosphatidylethanolamine biosynthesis
- inhibited by N-ethylmaleimide (putative)
Cofactor: Mg+2 (putative)
Structure:
- contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity
- contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif (putative)
- belongs to the lipin family
Compartment: nucleus (putative)
Alternative splicing: named isoforms=2
Expression:
- expressed in intestine & other regions of the GI tract
General
lipin
phosphoprotein
Properties
SIZE: entity length = 851 aa
MW = 94 kD
COMPARTMENT: cell nucleus
MOTIF: N-LIP {1-108}
nuclear translocation signal {141-148}
Thr phosphorylation site {T159}
Ser phosphorylation site {S161}
Ser phosphorylation site {S162}
Ser phosphorylation site {S204}
Ser phosphorylation site {S542}
C-LIP {590-792}
MOTIF: DXDXT {644-648}
LXXIL {655-659}
Database Correlations
OMIM 605520
UniProt Q9BQK8
PFAM correlations
Entrez Gene 64900
Kegg hsa:64900
ENZYME 3.1.3.4
References
- UniProt :accession Q9BQK8
- OMIM :accession 605520