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phosphatidate phosphatase LPIN2; lipin-2 (LPIN2, KIAA0249)
Function:
- roles in controlling metabolism of fatty acids at differents levels
- Mg+2-dependent phosphatidate phosphatase enzyme
- catalyzes conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine & phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane
- nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (putative)
- inhibited by N-ethylmaleimide (putative)
Cofactor: Mg+2 (putative)
Structure:
- contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity
- contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif (putative)
- belongs to the lipin family
Compartment:
- nucleus (putative)
- cytoplasm, cytosol (putative)
- endoplasmic reticulum membrane
- translocates to endoplasmic reticulum membrane with increasing levels of oleate (putative)
Expression:
- expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, & colon
Pathology:
- defects in LPIN2 are the cause of Majeed syndrome
General
lipin
phosphoprotein
Properties
SIZE: entity length = 896 aa
MW = 99 kD
COMPARTMENT: cytoplasm
cell nucleus
endoplasmic reticulum
MOTIF: N-LIP {1-108}
MOTIF: Ser phosphorylation site {S106}
nuclear translocation signal {153-158}
Ser phosphorylation site {S186}
Ser phosphorylation site {S187}
Ser phosphorylation site {S243}
Ser phosphorylation site {S245}
C-LIP {635-837}
MOTIF: DXDXT {689-693}
LXXIL {700-704}
Database Correlations
OMIM correlations
MORBIDMAP 605519
UniProt Q92539
PFAM correlations
Entrez Gene 9663
Kegg hsa:9663
ENZYME 3.1.3.4
References
- UniProt :accession Q92539
- INFEVERS; Note: repertory of FMF & hereditary autoinflammatory
disorders mutations
http://fmf.igh.cnrs.fr/ISSAID/infevers/disease_menu.php?n=7
- OMIM :accession 605519