phosphatidate phosphatase LPIN1; lipin-1 (LPIN1, KIAA0188)

Function: - roles in controlling metabolism of fatty acids at differents levels - Mg⁺²-dependent phosphatidate phosphatase - catalyzes conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine & phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane - also a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (putative) - role in adipocyte differentiation (putative) - inhibited by N-ethylmaleimide (putative) - phosphorylated at multiple sites in response to insulin - phosphorylation is controlled by the mTOR signaling pathway - dephosphorylated in response to epinephrine & oleic acid (putative) - sumoylated (putative) - interacts (via LXXIL motif) with PPARA (putative) - interacts with PPARGC1A (putative) - interaction with PPARA & PPARGC1A leads to the formation of a complex that modulates gene transcription (putative) - interacts with MEF2C Cofactor: Mg⁺² (putative) Structure: - contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL), a transcriptional binding motif, which mediates interaction with PPARA (putative) - contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity - belongs to the lipin family Compartment: - nucleus (putative) - cytoplasm, cytosol (putative) - endoplasmic reticulum membrane Expression: - abundant in adipose tissue & skeletal muscle - lower levels in some portions of the digestive tract Pathology: - defects in LPIN1 are a cause of acute recurrent rhabdomyolysis Note: - candidate gene for human lipodysytropy syndromes

General

lipin phosphomonoesterase phosphoprotein

Properties

SIZE: entity length = 890 aa MW = 99 kD COMPARTMENT: cytoplasm cell nucleus endoplasmic reticulum MOTIF: N-LIP {1-108} MOTIF: Ser phosphorylation site {S106} serine-rich region {147-150} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S150} nuclear translocation signal {153-158} Ser phosphorylation site {S252} Ser phosphorylation site {S254} Ser phosphorylation site {S260} Thr phosphorylation site {T264} Ser phosphorylation site {S294} Ser phosphorylation site {S434} Ser phosphorylation site {S438} Ser phosphorylation site {S449} serine-rich region {598-601} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S600} Ser phosphorylation site {S601} C-LIP {624-830} MOTIF: DXDXT {678-682} LXXIL {689-693} Ser phosphorylation site {S887} Ser phosphorylation site {S889}

Database Correlations

OMIM correlations MORBIDMAP 605518 UniProt Q14693 PFAM correlations Entrez Gene 23175 Kegg hsa:23175 ENZYME 3.1.3.4