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lipid phosphate phosphohydrolase 2; phosphatidate phosphohydrolase 2c; PAP2-gamma; PAP2-G (PPAP2C, LPP2)
Function:
- catalyzes the conversion of phosphatidic acid to diacylglycerol
- hydrolyzes lysophosphatidic acid, ceramide-1-phosphate & sphingosine-1-phosphate
- relative catalytic efficiency is phosphatidic acid > ceramide-1-phosphate > lysophosphatidic acid > sphingosine-1-phosphate
- inhibited by sphingosine, Zn+2 & propanolol
Structure:
- homodimer (putative)
- belongs to the PA-phosphatase related phosphoesterase family
Compartment: membrane
Expression: found mainly in brain, pancreas & placenta
General
glycoprotein
lipid phosphate phosphohydrolase; phosphatidate phosphohydrolase
transmembrane 6 protein
Properties
SIZE: MW = 33 kD
entity length = 288 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-4}
transmembrane domain {5-25}
exoplasmic loop {26-51}
transmembrane domain {52-72}
cytoplasmic loop {74-87}
transmembrane domain {88-108}
exoplasmic loop {116-164}
MOTIF: N-glycosylation site {N139}
transmembrane domain {163-183}
cytoplasmic loop {185-196}
transmembrane domain {197-217}
exoplasmic loop {218-226}
transmembrane domain {227-247}
cytoplasmic domain {248-288}
Database Correlations
OMIM 607126
UniProt O43688
Pfam PF01569
Kegg hsa:8612
ENZYME 3.1.3.4
References
UniProt :accession O43688