Search
lipid phosphate phosphatase-related protein type 4 (plasticity-related gene 1 protein, PRG-1, brain-specific phosphatidic acid phosphatase-like protein 1, LPPR4, KIAA0455, PRG1)
Function:
- hydrolyzes lysophosphatidic acid
- facilitates axonal outgrowth during development & regenerative sprouting
- in the outgrowing axons acts as an ecto-enzyme & attenuates phospholipid-induced axon collapse in neurons & facilitates outgrowth in the hippocampus
3-sn-phosphatidate + H2O a 1,2-diacyl-sn-glycerol + phosphate
Structure:
- belongs to the PA-phosphatase related phosphoesterase family
Compartment: membrane (putative)
Alternative splicing: named isoforms=2
Expression: specifically expressed in neurons
General
glycoprotein
lipid phosphate phosphatase-related protein (PA-phosphatase related phosphoesterase, LPPR)
phosphomonoesterase
phosphoprotein
Properties
SIZE: entity length = 763 aa
MW = 83 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {67-87}
transmembrane domain {119-139}
transmembrane domain {178-198}
N-glycosylation site {N214}
Ser phosphorylation site {S217}
N-glycosylation site {N219}
transmembrane domain {247-267}
N-glycosylation site {N268}
transmembrane domain {276-296}
transmembrane domain {308-328}
Ser phosphorylation site {S346}
N-glycosylation site {N362}
Thr phosphorylation site {T416}
N-glycosylation site {N432}
N-glycosylation site {N455}
N-glycosylation site {N513}
N-glycosylation site {N543}
N-glycosylation site {N568}
histidine-rich region {695-698}
MOTIF: histidine residue (SEVERAL)
Database Correlations
OMIM 607813
UniProt Q7Z2D5
Pfam PF01569
Kegg hsa:9890
ENZYME 3.1.3.4
References
UniProt :accession Q7Z2D5