Search
lipase member I; membrane-associated phosphatidic acid-selective phospholipase A1-beta; mPA-PLA1 beta; LPD lipase (LIPI, LPDL, PRED5)
Function:
1) hydrolyzes phosphatidic acid to lysophosphatidic acid
2) interacts with heparin
Inhibition:
- inhibited by sodium vanadate
Compartment: secreted, associate with lipid draft
Alternative splicing: named isoforms=2
Expression:
- expressed in testis
- expressed exclusively at connecting piece of the sperm
Pathology:
- defects in LIPI may be a cause of susceptibility to familial hypertrigliceridemia
General
glycoprotein
lipase
secreted protein
Properties
SIZE: MW = 53 kD
entity length = 460 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-15}
N-glycosylation site {N63}
serine residue {S159}
aspartate residue {D183}
cysteine residue {C238}
MODIFICATION: cysteine residue {C251}
cysteine residue {C251}
MODIFICATION: cysteine residue {C238}
histidine residue {H253}
cysteine residue {C275}
MODIFICATION: cysteine residue {C286}
cysteine residue {C286}
MODIFICATION: cysteine residue {C275}
cysteine residue {C289}
MODIFICATION: cysteine residue {C297}
cysteine residue {C297}
MODIFICATION: cysteine residue {C289}
N-glycosylation site {N396}
cysteine residue {C436}
MODIFICATION: cysteine residue {C455}
cysteine residue {C455}
MODIFICATION: cysteine residue {C436}
Database Correlations
OMIM 145750
UniProt Q6XZB0
ENZYME 3.1.1.-
References
UniProt :accession Q6XZB0