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lipase member H (membrane-associated phosphatidic acid-selective phospholipase A1-alpha, mPA-PLA1 alpha, LPD lipase-related protein, phospholipase A1 member B, LIPH, LPDLR, MPAPLA1, PLA1B)
Function:
1) hydrolyzes specifically phosphatidic acid produce lysophosphatidic acid
2) inhibited by sodium vanadate
Structure:
- belongs to the AB hydrolase superfamily, Lipase family
Compartment:
- secreted, membrane, peripheral membrane
Expression:
- present in intestine
- expressed in colon, prostate, kidney, pancreas, ovary, testis, intestine, lung & pancreas
- expressed at lower level in brain, spleen & heart
- in hair, it is prominently expressed in hair follicles, including stem cell-rich bulge region
Pathology:
- defects in LIPH are the cause of alopecia universalis congenita Mari type
General
glycoprotein
lipase
membrane protein
secreted protein
Properties
SIZE: MW = 51 kD
entity length = 451 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-18}
N-glycosylation site {N50}
N-glycosylation site {N66}
serine residue {S154}
aspartate residue {D178}
cysteine residue {C233}
MODIFICATION: cysteine residue {C246}
cysteine residue {C246}
MODIFICATION: cysteine residue {C233}
histidine residue {H248}
cysteine residue {C270}
MODIFICATION: cysteine residue {C281}
cysteine residue {C281}
MODIFICATION: cysteine residue {C270}
cysteine residue {C284}
MODIFICATION: cysteine residue {C292}
cysteine residue {C292}
MODIFICATION: cysteine residue {C284}
N-glycosylation site {N357}
cysteine residue {C427}
MODIFICATION: cysteine residue {C446}
cysteine residue {C446}
MODIFICATION: cysteine residue {C427}
Database Correlations
OMIM correlations
UniProt Q8WWY8
Pfam PF00151
References
UniProt :accession Q8WWY8