Lin-9 homolog (huLin-9, hLin-9, beta-subunit associated regulator of apoptosis, type 1 interferon receptor beta chain-associated protein, TUDOR gene similar protein, pRB-associated protein, LIN9, BARA, TGS)

Function: - acts as a tumor suppressor - inhibits DNA synthesis - ability to inhibit oncogenic transformation is mediated through association with RB1 - role in the expression of genes required for G1/S transition - interacts with RB1 Structure: belongs to the lin-9 family Compartment: - nucleus, nucleoplasm - found in perinucleolar structures - associated with chromatin Alternative splicing: named isoforms=3 Expression: expressed in thymus & testis

General

anti-oncoprotein (tumor suppressor protein) nuclear protein phosphoprotein

Properties

SIZE: MW = 62 kD entity length = 542 aa COMPARTMENT: cell nucleus MOTIF: Sufficient for interaction with RB1 {1-296} Ser phosphorylation site {S309} coiled coil {354-413}

Database Correlations

UniProt Q5TKA1 Pfam PF06584

References

UniProt :accession Q5TKA1