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PDZ & LIM domain protein 4; LIM protein RIL; reversion-induced LIM protein (PDLIM4, RIL)
Function:
- phosphorylated on Tyr
- can be dephosphorylated by PTPN13 (putative)
- interacts with the LIM domain with the 2nd & 4th PDZ domains of PTPN13 (putative)
Structure:
- contains 1 LIM Zn+2-binding domain
- contains 1 PDZ domain (DHR domain)
Alternative splicing: named isoforms=2
Expression:
- isoform 2 is found in brain
Polymorphism:
- genetic variations in PDLIM4 may be correlated with bone mineral density
General
PDZ & LIM domain protein
phosphoprotein
Properties
SIZE: entity length = 330 aa
MW = 35 kD
COMPARTMENT: cytoplasm
MOTIF: PDZ domain
NAME: PDZ domain
SITE: 1-84
Ser phosphorylation site {S112}
Ser phosphorylation site {S120}
LIM domain {253-312}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
Tyr phosphorylation site {Y316}
Database Correlations
OMIM 603422
UniProt P50479
PFAM correlations
Entrez Gene 8572
Kegg hsa:8572
References
UniProt :accession P50479