Search
LIM & SH3 domain protein 1; LASP-1; metastatic lymph node gene 50 protein; MLN 50 (LASP1, MLN50)
Function:
- role in regulation of dynamic actin-based, cytoskeletal activities
- agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, in parietal cells & in certain other F-actin-rich secretory epithelial cell types
- interacts with F-actin (putative)
Structure:
- contains 1 LIM Zn+2-binding domain
- contains 2 nebulin repeats
- contains 1 SH3 domain
Compartment:
- cytoplasm, cell cortex, cytoskeleton (putative)
- associated with the F-actin rich cortical cytoskeleton (putative)
Alternative splicing: named isoforms=2
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: entity length = 261 aa
MW = 30 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
LIM domain {5-56}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
Nebulin {61-95}
MOTIF: Thr phosphorylation site {T68}
Nebulin {97-131}
MOTIF: Thr phosphorylation site {T104}
Ser phosphorylation site {S146}
Ser phosphorylation site {S151}
Tyr phosphorylation site {Y171}
glycine-rich region {201-204}
src homology 3 [SH3] domain
SITE: 202-261
Database Correlations
OMIM 602920
UniProt Q14847
PFAM correlations
Entrez Gene 3927
Kegg hsa:3927
References
- UniProt :accession Q14847
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/Lasp1ID203.html