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lignan; enterodiol; enterolactone
Biochemistry:
- a low-molecular weight compound of plant origin (phytoestrogen) formed by coupling of monomeric precursors, including cinnamic acid, cinnamyl alcohol, propenylbenzene & allyl benzene
- they represent the dimer units from which lignins are made
- trimers & tetramers are not found naturally
- the lignans enterodiol & enterolactone are formed from enzymatic metabolism of secoisolariciresinol & matairesionol in the gastrointesional tract. [2]
Epidemiology:
- lignans are found in rye, linseed, carrots, tea, spinach, lettuce, broccoli, onions, flaxseed, tea & coffee
Pathology:
- higher serum enterolactone associated with lower mortality in patients with estrogen receptor negative breast cancer [3]
Interactions
drug adverse effects of estrogens
Related
lignin
phytoestrogen
General
phenol
Database Correlations
PUBCHEM correlations
References
- Merck Index, IIth ed, Merck & Co, Rahway NJ, 1989 # 5509
- Schabath MB et al.
Dietary phytoestrogens and risk of lung cancer
JAMA 2005 Sep 28;294(12):1493-504
PMID: 16189362
- Buck K et al.
Serum enterolactone and prognosis of postmenopausal breast
cancer.
J Clin Oncol 2011 Oct 1; 29:3730.
PMID: 21900115
- Patterson RE.
Flaxseed and breast cancer: What should we tell our patients?
J Clin Oncol 2011 Oct 1; 29:3723.
PMID: 21900107