ligase or synthetase

Enzyme catalyzing the joining together of two molecules with the accompanying hydrolysis of a high-energy bond [synthetase].

Specific

2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; AKB ligase; aminoacetone synthase; glycine acetyltransferase (GCAT, KBL) 5-formyltetrahydrofolate cyclo-ligase; 5,10-methenyl-tetrahydrofolate synthetase; methenyl-THF synthetase (MTHFS) acetyl CoA carboxylase acyl coenzyme-A [CoA] synthetase or acyl coenzyme-A [CoA] ligase acyl-CoA synthetase short-chain family member 3, mitochondrial (ACSS3) acyl-coenzyme A synthetase ACSM6, mitochondrial (ACSM6, C10orf129) adenylosuccinate synthetase isozyme 2 (IMP-aspartate ligase 2, AdSS 2, AMPSase 2, ADSS, ADSS2) amino acyl tRNA synthetase argininosuccinate synthetase (citrulline-aspartate ligase, ASS1, ASS) asparagine synthetase biotin-protein ligase; biotin apo-protein ligase; includes: biotin-[methylmalonyl-CoA-carboxytransferase] ligase; biotin-[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; holocarboxylase synthetase; HCS; biotin-[methylcrotonoyl-CoA-carboxylase] ligase; biotin-[acetyl-CoA-carboxylase] ligase (HLCS) carbamoyl phosphate synthase cytidine triphosphate [CTP] synthase; UTP-NH3 ligase (CTPS) DNA ligase E3 SUMO-protein ligase NSE2 (non-structural maintenance of chromosomes element 2 homolog, non-SMC element 2 homolog, hMMS21, NSMCE2, C8orf36, MMS21) E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein fatty acid synthase; includes: [acyl-carrier-protein] S-acetyltransferase; [acyl-carrier-protein] S-malonyltransferase; 3-oxoacyl-[acyl-carrier-protein] synthase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; enoyl-[acyl-carrier-protein] reductase; Oleoyl-[acyl-carrier-protein] hydrolase (FASN, FAS) folylpolyglutamate synthase, mitochondrial; folylpoly-gamma-glutamate synthetase; FPGS; tetrahydrofolylpolyglutamate synthase; tetrahydrofolate synthase (FPGS) gamma glutamyl cysteine synthetase geranoyl CoA carboxylase glutaconyl CoA carboxylase glutamate-cysteine ligase; gamma-glutamylcysteine synthetase glutamine synthetase; glutamate ammonia ligase (GLUL, GLNS) glutamine-dependent NAD+ synthetase; NAD+ synthase [glutamine-hydrolyzing]; NAD+ synthetase 1 (NADSYN1) Glutamyl-tRNA(Gln) amidotransferase subunit A homolog (glutaminyl-tRNA synthase-like protein 1, QRSL1) glutathione [GSH] synthetase (GSS) GMP synthase [glutamine-hydrolyzing]; GMP synthetase; glutamine amidotransferase (GMPS) lipoyltransferase 1, mitochondrial; lipoate biosynthesis protein; lipoate-protein ligase; lipoyl ligase (LIPT1) methylcrotonoyl CoA carboxylase methylmalonyl CoA carboxylase monofunctional C1-tetrahydrofolate synthase, mitochondrial (formyltetrahydrofolate synthetase, MTHFD1L, FTHFSDC1) multifunctional protein ADE2; phosphoribosylaminoimidazole succinocarboxamide synthase; SAICAR synthetase; phosphoribosylaminoimidazole carboxylase (ADE2, AIRC, PAICS, PAIS) NEDD8-activating enzyme E1 catalytic subunit; NEDD8-activating enzyme E1C; ubiquitin-activating enzyme E1C; ubiquitin-like modifier-activating enzyme 3; ubiquitin-activating enzyme 3 (UBA3, UBE1C) oxaloacetate carboxylase phenylalanyl-tRNA synthetase (phenylalanine-tRNA ligase) phenylalanyl-tRNA synthetase beta chain; phenylalanine-tRNA ligase beta chain (PheRS, FARSLB, FARS, FRSB, HSPC173) phosphopantothenate-cysteine ligase (phosphopantothenoylcysteine synthetase, PPC synthetase, PPCS, COAB) phosphoribosylformylglycinamidine synthase; FGAM synthase; FGAMS; formylglycinamide ribotide amidotransferase; FGARAT; formylglycinamide ribotide synthetase (PFAS, KIAA0361) pre-mRNA-processing factor 19 (PRP19/PSO4 homolog, hPso4, nuclear matrix protein 200, senescence evasion factor, PRPF19, NMP200, PRP19, SNEV) propionyl CoA carboxylase solute carrier family 27 member 1; long-chain fatty acid transport protein 1; fatty acid transport protein 1 (SLC27A1, FATP-1, ACSVL5, FATP1) solute carrier family 27 member 3 (SLC27A3, long-chain fatty acid transport protein 3, fatty acid transport protein 3, FATP-3, very long-chain acyl-CoA synthetase homolog 3, VLCS-3, ACSVL3, FATP3, UNQ367/PRO703) solute carrier family 27 member 4 (SLC27A4, long-chain fatty acid transport protein 4, fatty acid transport protein 4, FATP-4, ACSVL4, FATP4) solute carrier family 27 member 5 (SLC27A5, long-chain fatty acid transport protein 5, bile acyl-CoA synthetase, BACS, bile acid CoA ligase, BA-CoA ligase, BAL, cholate-CoA ligase, very long-chain acyl-CoA synthetase homolog 2, VLCSH2, VLCS-H2, very long chain acyl-CoA synthetase-related protein, VLACS-related, VLACSR, fatty-acid-coenzyme A ligase, very long-chain 3, fatty acid transport protein 5, FATP-5) some large E3 complex spliceosome SUMO ligase E3 (sentrin ligase E3) SUMO-conjugating protein-E2 (sentrin-conjugating protein-E2, SUMO carrier protein) transcription factor E4F1 (E3 ubiquitin-protein ligase E4F1, E4F transcription factor 1, transcription factor E4F, p120E4F, p50E4F, E4F1, E4F) tRNA-splicing ligase RtcB homolog (RTCB, C22orf28, HSPC117) tubulin polyglutamylase ubiquitin-activating enzyme E1 (ubiquitin-like modifier-activating enzyme 1, A1S9 protein, UBE1, UBA1, A1S9T) ubiquitin-activating enzyme E1-like protein 2; monocyte protein 4; MOP-4 (UBE1L2, UBA6, MOP4) ubiquitin-conjugating enzyme L-UBC ubiquitin-conjugating protein E2 (ubiquitin carrier protein) ubiquitin-like 1 [UBL1] activating enzyme E1 (SUMO-1 activating enzyme, UBLE1 ligase) urea carboxylase vitamin K-dependent gamma-carboxylase; gamma-glutamyl carboxylase; vitamin K gamma glutamyl carboxylase (GGCX, GC)

Properties

MOTIF: active site

References

Principles of Biochemistry 6th ed., White, Handler, Smith, Hill, & Lehman (eds.) McGraw-Hill, NY 1978, pg 202