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ligand-gated ion channel Zn+2-activated 1; ligand-gated ion-channel receptor L2 (LGICZ1, L2, LGICZ, ZACN, ZAC)
Function:
- Zn+2-activated ligand-gated ion channel
Structure:
- glycosylated
- belongs to the ligand-gated ionic channel (TC 1.A.9) family
Compartment: cell membrane
Alternative splicing: named isoforms=3
Expression:
- detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach & fetal brain
- in the adult brain, expression is detected in the hippocampus, striatum, amygdala & thalamus
Comparative biology:
- the mouse & rat orthologous proteins do not exist
Note: It is uncertain whether Met-1 or Met-2 is the initiator
General
evolutionary divergent protein
glycoprotein
ion channel
Properties
SIZE: entity length = 412 aa
MW = 46 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-25}
exoplasmic domain {26-233}
MOTIF: N-glycosylation site {N41}
N-glycosylation site {N55}
N-glycosylation site {N99}
cysteine residue {C157}
MODIFICATION: cysteine residue {C171}
N-glycosylation site {N170}
cysteine residue {C171}
MODIFICATION: cysteine residue {C157}
transmembrane domain {234-254}
cytoplasmic loop {255-265}
transmembrane domain {266-286}
exoplasmic loop {287-298}
transmembrane domain {299-319}
cytoplasmic loop {320-368}
transmembrane domain {369-389}
exoplasmic domain {390-412}
Database Correlations
UniProt Q401N2
Pfam PF02931
Kegg hsa:3531
References
UniProt :accession Q401N2