ligand-dependent corepressor; LCoR; Mblk1-related protein 2 (LCOR, KIAA1795, MLR2)

Function: 1) transcription activator (putative) -binds DNA sequence 5'-CCCTATCGATCGATCTCTACCT-3' 2) represses of ligand-dependent transcription activation by target nuclear receptors - ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA, VDR 3) interacts with ESR1, ESR2 in the presence of estradiol 4) interacts with CTBP1, HDAC3, HDAC6 5) component of large corepressor complex Structure: contains 1 HTH psq-type DNA-binding domain Compartment: nucleus Alternative splicing: named isoforms=2 Expression: ubiquitous

General

DNA-binding protein phosphoprotein transcriptional adaptor protein; transcriptional coactivator transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 433 aa MW = 47 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S37} Thr phosphorylation site {T40} Ser phosphorylation site {S42} Thr phosphorylation site {T44} Interaction with nuclear receptors {53-57} nuclear translocation signal {339-345} HTH psq-type {340-392} MOTIF: Ser phosphorylation site {S351} Ser phosphorylation site {S359} Ser phosphorylation site {S363} Ser phosphorylation site {S367} DNA-binding motif SITE: 368-388 Ser phosphorylation site {S430}

Database Correlations

OMIM 607698 UniProt Q96JN0 Pfam PF05225 Entrez Gene 84458 Kegg hsa:84458

References

UniProt :accession Q96JN0