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lichenoid eruption
Etiology:
1) pharmaceuticals
a) ACE inhibitors
- captopril
- enalapril
b) other antihypertensives
- beta-blockers [5]
- methyldopa
c) antibiotics
- tetracycline
- streptomycin
d) antimalarials
- quinacrine
- chloroquine
e) phenothiazines
- metopromazine
- levomepromazine
f) diuretics
- thiazide diuretics
- furosemide
g) hypoglycemic agents
- chlorpropamide
- tolazamide
h) NSAIDs [4]
i) miscellaneous agents
- gold salts
- p-amino-salicylic acid
- penicillamine
2) chemicals:
- color film developers
- p-phenylenediamine salts
- 2-amino-5-diethylaminotoluene monochloride (CD2)
- 4-amino-N-diethyl-aniline sulfate (TTS)
- antimony trioxide
Clinical manifestations:
- distribution may be photodistributed or generalized
- more eczematous, psoriaform or scaly than lichen planus
- usually does not involve mucosa
- Wickam striae uncommon Differential diagnois:
- lichen planus
Complications:
- malignant transformation of oral lesions (SCC) [6]
General
sign/symptom
References
- Harrison's Principles of Internal Medicine, 13th ed.
Companion Handbook, Isselbacher et al (eds), McGraw-Hill
Inc. NY, 1995, pg 829-39.
- Medical Knowledge Self Assessment Program (MKSAP) 15,
American College of Physicians, Philadelphia 2009
- Color Atlas & Synopsis of Clinical Dermatology, Common
& Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY,
1997, pg 268
- Geriatric Review Syllabus, 7th edition
Parada JT et al (eds)
American Geriatrics Society, 2010
- Geriatric Review Syllabus, 9th edition (GRS9)
Medinal-Walpole A, Pacala JT, Porter JF (eds)
American Geriatrics Society, 2016
- Fessa C, Lim P, Kossard S, Richards S, Penas PF.
Lichen planus-like drug eruptions due to beta-blockers:
a case report and literature review.
Am J Clin Dermatol. 2012 Dec 1;13(6):417-21. Review.
PMID: 22809321
- Fitzpatrick SG, Hirsch SA, Gordon SC.
The malignant transformation of oral lichen planus and oral
lichenoid lesions: a systematic review.
J Am Dent Assoc. 2014 Jan;145(1):45-56. Review.
PMID: 24379329