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Libman-Sacks endocarditis
Etiology:
- systemic lupus erythematosus
- antiphospholipid antibody syndrome
Epidemiology:
- 11% of patients with systemic lupus erythematosus
Pathology:
- non-infectious thrombotic endocarditis
- large verrucous lesions near the edge of the mitral valve (most common)
- lesions consist of immune complexes. mononuclear cells, & fibrin & platelet thrombi
Clinical manifestations:
- generally asymptomatic
Complications:
- transient ischemic attack or embolic stroke
- infectious endocarditis
General
endocarditis
References
- Medical Knowledge Self Assessment Program (MKSAP) 18,
American College of Physicians, Philadelphia 2018