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Lutropin-choriogonadotropic hormone receptor; LH/CG-R; LSH-R; Luteinizing hormone receptor; LHR (LHCGR, LCGR, LGR2 LHRHR)
Function:
- receptor for LH hormone
- activity is mediated by G proteins which activate adenylate cyclase
- activation results in secretion of testosterone & estradiol by Leydig cells & secretion of androstenedione (& other androgens) aromatized to estradiol by adjacent granulosa cells.
Structure:
- belongs to the G-protein coupled receptor 1 family FSH/LSH/TSH subfamily
- contains 7 LRR repeats (leucine-rich repeats)
Compartment: cell membrane
Alternative splicing: named isoforms=2
Additional isoforms seem to exist
Expression:
- expressed in gonadal & thyroid cells
- expressed by Leydig cells of the testes & theca cells of the ovary
Pathology:
- defects in LHCGR are a cause of
a) familial male precocious puberty
b) Leydig cell hypoplasia
Interactions
molecular events
Related
chorionic gonadotropin; choriogonadotropin (APL, hCG)
luteinizing hormone; lutropin (LH)
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 699 aa
MW = 79 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-26}
exoplasmic domain {27-363}
MOTIF: leucine-rich repeat
SITE: 48-71
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 97-121
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N99}
leucine-rich repeat
SITE: 122-147
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 149-171
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 172-196
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N174}
N-glycosylation site {N195}
leucine-rich repeat
SITE: 197-220
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 221-244
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N291}
N-glycosylation site {N299}
N-glycosylation site {N313}
transmembrane domain {364-385}
cytoplasmic loop {386-395}
transmembrane domain {396-416}
exoplasmic loop {417-439}
MOTIF: cysteine residue {C439}
MODIFICATION: cysteine residue {C514}
transmembrane domain {440-462}
cytoplasmic loop {463-482}
transmembrane domain {483-505}
exoplasmic loop {506-525}
MOTIF: cysteine residue {C514}
MODIFICATION: cysteine residue {C439}
transmembrane domain {526-549}
cytoplasmic loop {550-570}
transmembrane domain {571-594}
exoplasmic loop {595-605}
transmembrane domain {606-627}
cytoplasmic domain {628-699}
MOTIF: cysteine residue {C643}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C644}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM correlations
UniProt P22888
Pfam PF00001
Entrez Gene 3973
References
- UniProt :accession P22888
- Human luteinizing hormone receptor mutation db
http://www.eur.nl/fgg/endov/lhr.html
- GRIS; Note: glycoprotein-hormone receptors information system
http://gris.ulb.ac.be/
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/LHRID288.html
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=LHCGR