Search
CD58; lymphocyte function-associated antigen 3; Ag3; Surface glycoprotein LFA-3 (LFA3)
Function:
- ligand for CD2
- mediates adhesion between:
a) NK cells & target cells
b) antigen presenting cells & T cells
c) thymocytes & thymic epithelial cells
- mediates T-lymphocyte rosetting with erythrocytes
- the LFA-3/CD2 interaction may prime response by both the CD2+ & LFA-3+ cells
Structure:
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
Compartment:
- isoform 1: cell membrane
- isoform 2: cell membrane; lipid-anchor, GPI-anchor
Alternative splicing: named isoforms=2
Expression:
- GPI-anchored form. may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
- leukocytes
- erythrocytes
- endothelial cells
- epithelial cells
- fibroblasts
Interactions
molecular events
Related
lymphocyte
General
adhesion receptor
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
immunoglobulin superfamily protein
Properties
SIZE: entity length = 250 aa
MW = 28 kD
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-28}
N-glycosylation site {N40}
N-glycosylation site {N94}
N-glycosylation site {N109}
immunoglobulin superfamily domain {135-194}
MOTIF: N-glycosylation site {N135}
cysteine residue {C142}
MODIFICATION: cysteine residue {C187}
N-glycosylation site {N169}
cysteine residue {C187}
MODIFICATION: cysteine residue {C142}
N-glycosylation site {N195}
transmembrane domain {216-238}
MOTIF: glycosyl phosphatidylinositol [GPI] membrane anchor {N235}
Database Correlations
OMIM 153420
UniProt P19256
Entrez Gene 965
Kegg hsa:965
References
- Altman A, Coggeshall KM, Mustelin T.
Molecular events mediating T cell activation.
Adv Immunol. 1990;48:227-360. Review.
PMID: 1693465
- Webb DS et al
LFA-3, CD44, and CD45: physiologic triggers of human monocyte
TNF and IL-1 release.
Science 249:1295 1990
PMID: 1697984
- UniProt :accession P19256
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- Entrez Gene :accession 965