leukotriene C4 synthase; LTC4 synthase; leukotriene-C(4) synthase (LTC4S)

Function: - catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 - interacts with ALOX5AP & ALOX5 Leukotriene C4 = leukotriene A4 + glutathione Structure: - homotrimer - belongs to the MAPEG family Compartment: - nuclear outer membrane - endoplasmic reticulum membrane - multi-pass membrane protein Expression: - detected in lung, platelets & the myelogenous leukemia cell line KG-1 (at protein level) - LTC4S activity is present in eosinophils, basophils, mast cells, some phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells & platelets Pathology: - defects in LTC4S are the cause of leukotriene C4 synthase deficiency

General

lyase nuclear protein transmembrane 3 protein

Properties

SIZE: entity length = 150 aa MW = 17 kD COMPARTMENT: cell nucleus endoplasmic reticulum MOTIF: cytoplasmic domain {1-6} transmembrane domain {7-27} exoplasmic loop {28-48} MOTIF: binding site SITE: 30-30 FOR-BINDING-OF: Glutathione arginine residue {R31} transmembrane domain {49-69} MOTIF: Glutathione binding {51-55} Glutathione binding {58-59} cytoplasmic loop {70-73} transmembrane domain {74-94} Glutathione binding {93-97} exoplasmic loop {95-104} MOTIF: arginine residue {R104} transmembrane domain {105-124} cytoplasmic domain {125-150}

Database Correlations

OMIM 246530 UniProt Q16873 Pfam PF01124 Entrez Gene 4056 Kegg hsa:4056 ENZYME 4.4.1.20

References

UniProt :accession Q16873