leukotriene B4 receptor 2 (LTB4-R2, 7 transmembrane receptor BLTR2, leukotriene B4 receptor BLT2, LTB4 receptor JULF2)

Function: - low-affinity receptor for leukotrienes including LTB4 - mediates chemotaxis of granulocytes & macrophages - G-protein-linked IP3-Ca⁺² second messenger system - rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3 Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - widely expressed Note: uncertain whether Met-1 or Met-32 is the initiator

General

glycoprotein leukotriene receptor G-protein coupled receptor; serpentine receptor

Properties

SIZE: MW = 42 kD entity length = 389 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-55} MOTIF: N-glycosylation site {N41} transmembrane domain {56-76} cytoplasmic loop {77-91} transmembrane domain {92-112} exoplasmic loop {113-127} transmembrane domain {128-148} cytoplasmic loop {149-172} transmembrane domain {173-193} exoplasmic loop {194-216} transmembrane domain {217-237} cytoplasmic loop {238-256} transmembrane domain {257-277} exoplasmic loop {278-306} transmembrane domain {307-327} cytoplasmic domain {328-389}

Database Correlations

OMIM 605773 UniProt Q9NPC1 Pfam PF00001 Kegg hsa:5641

References

UniProt :accession Q9NPC1