Search
Leukocyte tyrosine kinase receptor; protein tyrosine kinase 1 (LTK, TYK1)
Function:
- function unknown
- probably a receptor with tyrosine kinase activity
- may receptor for a pre-B lymphocyte growth or differentiation factor
Structure:
- belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
- contains 1 protein kinase domain
Compartment: membrane
Alternative splicing: named isoforms=4 Additional isoforms seem to exist
Expression:
- expressed in non-hematopoietic cell lines & T-cell & B-cell lines
Comparative biology:
- mouse protein may lack an extracellular domain [2]
- mouse mRNA contains non AUG translation initiator
General
glycoprotein
tyrosine kinase receptor (RTK)
Properties
SIZE: entity length = 864 aa
MW = 92 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-16}
N-glycosylation site {N257}
N-glycosylation site {N380}
N-glycosylation site {N412}
transmembrane domain {425-449}
kinase domain
SITE: 510-786
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 516-524
ATP-binding site
NAME: ATP-binding site
SITE: 544-544
aspartate residue {D643}
Tyr phosphorylation site {Y672}
Tyr phosphorylation site {Y676}
Tyr phosphorylation site {Y677}
Database Correlations
OMIM 151520
UniProt P29376
Pfam PF07714
Kegg hsa:4058
ENZYME 2.7.10.1
References
- UniProt :accession P29376
- Bernards A, de la Monte SM.
The ltk receptor tyrosine kinase is expressed in pre-B
lymphocytes and cerebral neurons and uses a non-AUG
translational initiator.
EMBO J. 1990 Jul;9(7):2279-87.
PMID: 2357970