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leukocyte histamine release test
In vitro test that measures the amount of histamine released from leukocytes after exposure to antigen.
Procedure:
- an allergen extract (varyible concentrations) is added to peripheral blood leukocytes
- histamine is normally released in response to interaction of allergen with cell surface IgE antibodies
Clinical significance:
- patients hypersensitive to a specific antigen will show histamine release
Notes:
- variability in results [1]
Related
histamine
Specific
basophil histamine release test
General
provocative clinical test
References
- Allergy Testing - Leukocyte Histamine Release Test (LHRT)
BlueCross BlueShield of Tennessee Medical Policy Manual
http://www.bcbst.com/mpmanual/Allergy_Testing_-_Leukocyte_Histamine_Release_Test_LHRT.htm
- Mata E et al
Clinical evaluation of in vitro leukocyte histamine release
in allergy to muscle relaxant drugs.
Allergy. 1992 Oct;47(5):471-6.
PMID: 1283060
- Leukocyte Histamine Release Test
BlueCross of Idaho
https://www.bcidaho.com/providers/medical_policies/med/mp_20442.asp