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leukocyte cell derived chemotaxin 1 (LECT1, chondromodulin-1, CHMI)
Function:
1) growth regulator
2) stimulates the growth of cultured chondrocytes in presence of basic fibroblast growth factor
3) inhibits the growth of cultured vascular endothelial cell
4) replacement of cartilage by bone during endochondral bone development (putative)
Compartment:
- cytoplasm, secreted protein
- inter-territorial matrix of cartilage
Expression:
- cartilage specific
Pathology: weakly expressed in chondrosarcoma
General
glycoprotein
leukocyte cell derived chemotaxin (lect)
membrane protein
Properties
SIZE: MW = 37 kD
entity length = 334 aa
COMPARTMENT: extracellular compartment
MOTIF: transmembrane domain {45-65}
BRICHOS {104-201}
N-glycosylation site {N243}
cysteine residue {C282}
MODIFICATION: cysteine residue {C286}
cysteine residue {C283}
MODIFICATION: cysteine residue {C323}
cysteine residue {C286}
MODIFICATION: cysteine residue {C282}
cysteine residue {C323}
MODIFICATION: cysteine residue {C283}
Database Correlations
OMIM 605147
UniProt O75829
Pfam PF04089
Entrez Gene 11061