Search
leukemia inhibitory factor; melanoma-derived LPL inhibitor; differentiation-stimulating factor; D factor,; HILDA; MLPLI; emfilermin (LIF)
Function:
- similar in it's activities to IL-6
- LIF has the capacity to induce terminal differentiation in leukemic cells
- activities include
a) induction of hematopoietic differentiation in normal & myeloid leukemia cells
b) induction of neuronal cell differentiation
c) stimulation of acute-phase protein synthesis in hepatocytes
Structure: belongs to the LIF/OSM family
Compartment: secreted
Expression: induced by IL-1 in sympathetic ganglia Pharmacolology:
- in phase II clinical trial, ddeveloped by Amrad to assist embryo implantation in women who have failed to become pregnant despite assisted reproductive technologies
General
cytokine
glycoprotein
Properties
SIZE: entity length = 202 aa
MW = 22 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
N-glycosylation site {N31}
cysteine residue {C34}
MODIFICATION: cysteine residue {C156}
cysteine residue {C40}
MODIFICATION: cysteine residue {C153}
N-glycosylation site {N56}
cysteine residue {C82}
MODIFICATION: cysteine residue {C185}
N-glycosylation site {N85}
N-glycosylation site {N95}
N-glycosylation site {N118}
N-glycosylation site {N138}
cysteine residue {C153}
MODIFICATION: cysteine residue {C40}
cysteine residue {C156}
MODIFICATION: cysteine residue {C34}
cysteine residue {C185}
MODIFICATION: cysteine residue {C82}
Database Correlations
OMIM 159540
UniProt P15018
Pfam PF01291
Entrez Gene 3976
Kegg hsa:3976
References
- Gearing DP, Comeau MR, Friend DJ, Gimpel SD, Thut CJ,
McGourty J, Brasher KK, King JA, Gillis S, Mosley B, et al.
The IL-6 signal transducer, gp130: an oncostatin M receptor
and affinity converter for the LIF receptor.
Science. 1992 Mar 13;255(5050):1434-7.
PMID: 1542794
- Hopkins SJ & Rothwell NJ
Cytokines and the nervous system. I: Expression and recognition.
TINS 18:83 1995
PMID: 7537419
- Entrez Gene :accession 3976
- Wikipedia leukemia inhibitory factor entry
http://en.wikipedia.org/wiki/Leukemia_inhibitory_factor
- UniProt :accession P15018