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leucine-zipper-like transcriptional regulator 1 (LZTR1, TCFL2)

Function: 1) transcriptional regulator 2) role in embryogenesis (putative) Structure: - contains 2 BTB (POZ) domains contains 6 Kelch repeats Expression: - expressed in fetal brain, heart, kidney, liver, lung Pathology: - role in etiology of velocardiofacial/DiGeorge syndromes

General

transcription factor (TF)

Properties

SIZE: MW = 95 kD entity length = 840 aa COMPARTMENT: cell nucleus MOTIF: kelch repeat {79-128} kelch repeat {130-185} kelch repeat {187-238} kelch repeat {239-285} kelch repeat {295-341} kelch repeat {399-450} BTB domain {443-537} MOTIF: Zinc finger NAME: Zinc finger EFFECTOR-BOUND: Zn+2 BTB domain {667-736} MOTIF: Zinc finger NAME: Zinc finger EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 600574 UniProt Q8N653 PFAM correlations

References

UniProt :accession Q8N653