leucine-rich repeat transmembrane neuronal 2 protein; leucine-rich repeat neuronal 2 protein (KIAA0416, LRRTM2)

Function: - role in the development & maintenance of excitatory synapse in the vertebrate nervous system - regulates surface expression of AMPA receptors - acts as a ligand for the presynaptic receptors NRXN1-A & NRXN1-B (putative) - interacts with DLG4 & NRXN1 (putative) Structure: - synaptogenic effects are mediated by the extracellular LRR region (putative) - belongs to the LRRTM family - contains 10 LRR repeats (leucine-rich repeats) - contains 1 LRRCT domain - contains 1 LRRNT domain Compartment: - cell membrane - cell junction, synapse, postsynaptic cell membrane - single-pass type 1 membrane protein (putative) - localized to excitatory synapses (putative) Expression: - expressed in neuronal tissues Notes: - appears to be same as leucine-rich repeat neuronal protein 2

General

glycoprotein membrane protein

Properties

SIZE: MW = 59 kD entity length = 516 aa COMPARTMENT: cellular membrane MOTIF: N-glycosylation site {N57} leucine-rich repeat SITE: 61-83 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 84-107 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 109-131 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N126} leucine-rich repeat SITE: 132-155 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 156-179 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 181-203 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 205-227 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 229-251 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N243} leucine-rich repeat SITE: 252-275 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 276-299 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N362} transmembrane domain {423-443}

Database Correlations

OMIM 610868 UniProt O43300 Pfam PF12799 Entrez Gene 26045 Kegg hsa:26045

References

UniProt :accession O43300