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leucine-rich repeat serine/threonine-protein kinase 1 (LRRK1, KIAA1790)
Function:
- binding of GTP stimulates kinase activity
Cofactor: Mg+2, Mn+2
Structure:
- belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, ROCO subfamily
- contains 4 ANK repeats
- contains 13 LRR repeats (leucine-rich repeats)
- contains 1 protein kinase domain
- contains 1 Roc domain
Compartment: cytoplasm
Alternative splicing: named isoforms=2
General
ankyrin repeat domain protein (ANKRD)
leucine-rich repeat-containing protein (LRRC)
serine/threonine kinase
Properties
SIZE: entity length = 2015 aa
MW = 225 kD
COMPARTMENT: cytoplasm
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 86-116
ankyrin repeat
NAME: ankyrin repeat
SITE: 119-148
ankyrin repeat
NAME: ankyrin repeat
SITE: 152-182
ankyrin repeat
NAME: ankyrin repeat
SITE: 193-222
leucine-rich repeat
SITE: 279-300
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 303-324
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 330-351
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 353-374
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 381-402
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 405-426
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 427-447
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 451-472
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 474-495
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 498-519
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 549-570
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 572-594
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 596-617
MOTIF: leucine residue (SEVERAL)
Roc {632-826}
kinase domain
SITE: 1242-1525
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 1248-1256
ATP-binding site
NAME: ATP-binding site
SITE: 1270-1270
aspartate residue {D1386}
STATE: active state
Database Correlations
OMIM 610986
UniProt Q38SD2
PFAM correlations
Entrez Gene 79705
Kegg hsa:79705
ENZYME 2.7.11.1
References
UniProt :accession Q38SD2