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leucine-rich repeat neuronal protein 2; leucine-rich repeat neuronal protein 5; glioma amplified on chromosome 1 protein (LRRN2, GAC1, LRRN5, UNQ256/PRO293)
Structure:
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 11 LRR repeats (leucine-rich repeats)
Compartment:
- membrane; single-pass type 1 membrane protein (putative)
- overamplified in malignant gliomas
Expression:
- brain, adult - high levels
- heart & kidney, adult - lower levels
Pathology: over-amplified in malignant gliomas
Related
leucine-rich repeat & immunoglobulin-like domain-containing nogo receptor-interacting protein 3; leucine-rich repeat neuronal protein 6B; leucine-rich repeat neuronal protein 2 (LINGO3, LERN2, LRRN6B)
leucine-rich repeat transmembrane neuronal 2 protein; leucine-rich repeat neuronal 2 protein (KIAA0416, LRRTM2)
General
glycoprotein
leucine-rich repeat-containing protein (LRRC)
membrane protein
Properties
SIZE: entity length = 713 aa
MW = 79 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-18}
leucine-rich repeat
SITE: 92-115
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N94}
leucine-rich repeat
SITE: 116-139
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 140-163
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 165-187
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 188-211
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 213-235
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 236-259
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 261-283
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 309-333
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 334-357
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 359-385
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N381}
immunoglobulin superfamily domain {422-511}
MOTIF: cysteine residue {C445}
MODIFICATION: cysteine residue {C497}
cysteine residue {C497}
MODIFICATION: cysteine residue {C445}
N-glycosylation site {N555}
N-glycosylation site {N583}
transmembrane domain {631-651}
Database Correlations
OMIM 605492
UniProt O75325
Pfam PF00560
Entrez Gene 10446
Kegg hsa:10446
References
UniProt :accession O75325