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leucine-rich repeat-containing protein 33; negative regulator of reactive oxygen species (LRRC33 NRROS UNQ3030/PRO9833)
Function:
- may play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation & cytokine production
- interacts (via LRR repeats) with TLR2, TLR3, TLR4, TLR9 & probably other Toll-like receptors
Structure: contains 21 LRR repeats (leucine-rich repeats)
Compartment:
- cell membrane
- single-pass type 1 membrane protein
Expression:
- ubiquitous,
- high level of expression found in bone marrow, thymus, liver, lung, intestine & spleen
General
glycoprotein
leucine-rich repeat-containing protein (LRRC)
membrane protein
Properties
SIZE: entity length = 692 aa
MW = 76 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-18}
N-glycosylation site {N21}
leucine-rich repeat
SITE: 58-79
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N74}
leucine-rich repeat
SITE: 82-103
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 106-127
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 133-155
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N155}
leucine-rich repeat
SITE: 158-179
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 182-203
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 206-227
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 228-239
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N232}
leucine-rich repeat
SITE: 251-272
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 273-294
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N292}
N-glycosylation site {N309}
N-glycosylation site {N312}
leucine-rich repeat
SITE: 329-350
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 353-374
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 377-398
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 403-424
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N408}
leucine-rich repeat
SITE: 427-447
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N427}
leucine-rich repeat
SITE: 463-484
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 486-507
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N500}
leucine-rich repeat
SITE: 512-534
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 537-558
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 559-580
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 585-594
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N622}
transmembrane domain {651-671}
Database Correlations
OMIM 615322
UniProt Q86YC3
Pfam PF00560
Entrez Gene 375387
Kegg hsa:375387
References
UniProt :accession Q86YC3