leucine-rich repeat-containing protein 25 (monocyte & plasmacytoid-activated protein, LRRC25, MAPA, UNQ6169/PRO20174)

Function: - role in activation of cells of innate & acquired immunity Structure: - contains 2 LRR repeats (leucine-rich repeats) Compartment: membrane Expression: - expressed in plasmacytoid dendritic cells, monocyte-derived dendritic cells, granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow > lymph nodes, fetal liver, appendix - down-regulated in CD40-activated monocyte-derived dendritic cells

General

glycoprotein leucine-rich repeat-containing protein (LRRC) membrane protein

Properties

SIZE: MW = 33 kD entity length = 305 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-20} N-glycosylation site {N44} N-glycosylation site {N55} leucine-rich repeat SITE: 62-85 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 86-109 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N130} N-glycosylation site {N148} transmembrane domain {166-186}

Database Correlations

OMIM 607518 UniProt Q8N386

References

UniProt :accession Q8N386