leucine-rich repeat & fibronectin type III domain-containing protein 1 (synaptic adhesion-like molecule 2, LRFN1, KIAA1484, SALM2)

Function: - role in the regulation of excitatory synapses - interacts with DLG1, DLGAP1, AMPA receptors & NMDA receptors (putative) - interacts with DLG4 - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - glycosylated (putative) - belongs to the LRFN family - contains 1 fibronectin F3 module - contains 1 Ig-like (immunoglobulin-like) domain - contains 7 LRR repeats (leucine-rich repeats) Compartment: membrane, cell junction, synapse (putative)

General

glycoprotein leucine-rich repeat-containing protein (LRRC) membrane protein phosphoprotein

Properties

SIZE: entity length = 771 aa MW = 82 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-31} leucine-rich repeat SITE: 64-87 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N87} leucine-rich repeat SITE: 88-111 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 112-135 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 136-159 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 161-184 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 185-208 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 209-233 MOTIF: leucine residue (SEVERAL) immunoglobulin superfamily domain {299-386} MOTIF: cysteine residue {C321} MODIFICATION: cysteine residue {C370} N-glycosylation site {N343} cysteine residue {C370} MODIFICATION: cysteine residue {C321} fibronectin type III domain or F3 module {421-512} transmembrane domain {537-557} Ser phosphorylation site {S613}

Database Correlations

UniProt Q9P244 PFAM correlations

References

UniProt :accession Q9P244