Lethal(2) giant larvae protein homolog 1 (LLGL, human homolog to the D-lgl gene, Hugl-1, DLG4, LLGL1, HUGL)

Function: 1) cortical cytoskeleton protein 2) found in a complex involved in maintaining cell polarity & epithelial integrity 3) role in regulation of mitotic spindle orientation, proliferation, differentiation & tissue organization of neuroepithelial cells 4) associated with nonmuscle myosin II heavy chain 5) interacts with PRKCI/aPKC, PARD6B/Par-6, PARD6A 6) interacts with STX4A 7) phosphorylated on Ser-664 by PRKCI 8) expression increases cell adhesion & decreases cell migration Structure: - contains 6 WD repeats Compartment: - cytoplasm - localized to lateral membrane during cell polarization & formation of cell-cell contacts Expression: expressed in brain, kidney, muscle >> heart, placenta Pathology: 1) down-regulation of LLGL1 is associated with progression of colorectal cancer & melanoma 2) deleted in Smith-Magenis syndrome

General

cytoskeletal protein WD repeat protein family

Properties

SIZE: MW = 115 kD entity length = 1062 aa COMPARTMENT: cytoplasm MOTIF: WD repeat {32-71} WD repeat {73-112} WD repeat {194-234} WD repeat {236-275} WD repeat {428-471} Ser phosphorylation site {S664} WD repeat {718-755}

Database Correlations

OMIM 600966 UniProt Q15334 PFAM correlations

References

UniProt :accession Q15334