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lens fiber membrane intrinsic protein (MP18, MP19, MP20, LIM2)
Function:
1) found in thicker 16-17 nm junctions of mammalian lens fiber cells, may contribute to cell junctional organization
2) receptor for calmodulin
3) role in both lens development & cataractogenesis (putative)
4) associated with itself or another lens membrane component via disulfide bonds
5) phosphorylated by cAMP-dependent kinase & protein kinase C
Compartment: membrane
Alternative splicing: named isoforms=2
Expression: eye lens specific
General
glycoprotein
phosphoprotein
transmembrane 4 protein
Properties
SIZE: MW = 20 kD
entity length = 173 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-3}
transmembrane domain {4-24}
exoplasmic loop {25-66}
MOTIF: N-glycosylation site {N62}
transmembrane domain {67-87}
cytoplasmic loop {88-98}
transmembrane domain {99-119}
exoplasmic loop {120-140}
transmembrane domain {141-161}
cytoplasmic domain {162-173}
Database Correlations
OMIM 154045
UniProt P55344
Pfam PF00822
References
UniProt :accession P55344