Contents

Search

lenadogene nolparvovec (Lumevoq)

Indications: - gene therapy for Leber hereditary optic neuropathy (LHON) with MT-ND4 gene mutation* * not FDA-approved Dosage: - intravitreal injection Mechanism of action: - uses adeno-associated virus vector to deliver wild-type MT-ND4 gene directly to the mitochondrial membrane of retinal ganglion cells.

General

gene therapy ophthalmic agent (eyedrops)

References

  1. Davenport L Gene Therapy Promising for Reversal of Hereditary Vision Loss. Medscape. June 13, 2023 https://www.medscape.com/viewarticle/994339