LEM domain-containing protein 2 (hLEM2) (LEMD2)

Function: - role in nuclear structure organization - binds to the lamin tail, in vitro Structure: contains 1 LEM domain Compartment: - nucleus inner membrane - lamina-associated protein residing in the inner nuclear membrane - localized exclusively to the nuclear envelope, giving rise to a typical rim-like staining of the nuclear periphery Expression: ubiquitously expressed

General

LEM domain-containing protein (LEMD) membrane protein nuclear protein phosphoprotein

Properties

SIZE: MW = 57 kD entity length = 503 aa COMPARTMENT: nuclear membrane MOTIF: LEM domain {1-42} lamin A/C interaction {74-103} transmembrane domain {213-233} serine-rich region {314-317} MOTIF: serine residue (SEVERAL) transmembrane domain {377-397} glutamate-rich region {405-408} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S499} Ser phosphorylation site {S501}

Database Correlations

UniProt Q8NC56 Pfam PF03020

References

UniProt :accession Q8NC56