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leiomodin-2 (cardiac leiomodin, C-LMOD, LMOD2)
Function:
- may block the elongation & depolymerization of the actin filaments at the pointed end
- able to bind to tropomyosin (putative)
Structure:
- belongs to the tropomodulin family
- contains 1 WH2 domain
Alternative splicing: named isoforms=3
Expression:
- specifically expressed in heart & skeletal muscles
- not expressed in other tissues
General
cytoskeletal protein
Properties
SIZE: entity length = 547 aa
MW = 62 kD
COMPARTMENT: cytoplasm
MOTIF: binding site
SITE: 1-42
FOR-BINDING-OF: tropomyosin
glutamate-rich region {14-142}
MOTIF: glutamate residue (SEVERAL)
coiled coil {16-41}
coiled coil {113-148}
proline-rich region
SITE: 385-450
MOTIF: proline residue (SEVERAL)
lysine-rich region {478-487}
MOTIF: lysine residue (SEVERAL)
WH2 {521-540}
Database Correlations
OMIM 608006
UniProt Q6P5Q4
PFAM correlations
References
UniProt :accession Q6P5Q4