legumain; asparaginyl endopeptidase; protease, cysteine 1 (LGMN, PRSC1)

Function: - strict specificity for hydrolysis of asparaginyl bonds - can also cleave aspartyl bonds slowly, especially under acidic conditions - may be involved in the processing of proteins for MHC class 2 antigen presentation in the lysosomal/endosomal system - hydrolysis of proteins & small molecule substrates at -Asn-|-Xaa- bonds Structure: - glycosylated - belongs to the peptidase C13 family Compartment: lysosome (putative) Expression: - ubiquitous - particularly abundant in kidney, heart & placenta

General

glycoprotein protease; proteinase; endopeptidase

Properties

SIZE: entity length = 433 aa MW = 49 kD COMPARTMENT: lysosome MOTIF: signal sequence {1-17} N-glycosylation site {N91} histidine residue {H148} N-glycosylation site {N167} cysteine residue {C189} N-glycosylation site {N263} N-glycosylation site {N272} proteolytic site {323-324}

Database Correlations

OMIM 602620 UniProt Q99538 Pfam PF01650 Entrez Gene 5641 KEGG correlations ENZYME 3.4.22.34

References

UniProt :accession Q99538