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Legionella antigen in urine

Indications: - rule out Legionellosis (Legionnaire's disease) Clinical significance: - sensitivity: 60%--80%; specificity: >99% for Legionella pneumophila serogroup 1 - does not detect other Legionella strains [2] - can remain positive for long periods after resolution of infection [2] - sensitivity 62.5%; false negatives 37.5% [3]

Related

Legionella

General

Legionella antigen in tissue/body fluid urine chemistry test

References

  1. Centers for Disease Control and Prevention (CDC) Legionellosis --- United States, 2000--2009 MMWR. August 19, 2011 / 60(32);1083-1086 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6032a3.htm
  2. Medical Knowledge Self Assessment Program (MKSAP) 18, American College of Physicians, Philadelphia 2018
  3. Muyldermans A, Descheemaeker P, Boel A et al. What is the risk of missing legionellosis relying on urinary antigen testing solely? A retrospective Belgian multicenter study. Eur J Clin Microbiol Infect Dis 2019 Dec 14 PMID: 31838606 https://link.springer.com/article/10.1007%2Fs10096-019-03785-8