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left-right determination factor B; lefty-B protein (LEFTB, LEFTYB, LEFTY1, UNQ278/PRO317)
Function:
1) left-right asymmetry determination of organ systems in mammals
2) processing may occur at 2nd R-X-X-R site at AA 132-135
3) processing regulated in a cell-type specific manner
Compartment: secreted
General
glycoprotein
secreted protein
Properties
SIZE: MW = 41 kD
entity length = 366 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
N-glycosylation site {N158}
cysteine residue {C251}
MODIFICATION: cysteine residue {C264}
cysteine residue {C263}
MODIFICATION: cysteine residue {C316}
cysteine residue {C264}
MODIFICATION: cysteine residue {C251}
cysteine residue {C293}
MODIFICATION: cysteine residue {C351}
cysteine residue {C297}
MODIFICATION: cysteine residue {C353}
cysteine residue {C316}
MODIFICATION: cysteine residue {C263}
cysteine residue {C351}
MODIFICATION: cysteine residue {C293}
cysteine residue {C353}
MODIFICATION: cysteine residue {C297}
Database Correlations
OMIM 603037
UniProt O75610
PFAM correlations
References
UniProt :accession O75610