layilin (LAYN)

Function: - receptor for hyaluronate - interacts with NF2, RDX & TLN1 - C-terminal domain interacts with the N-terminal domain of RDX Structure: - contains 1 C-type lectin domain Compartment: - membrane - colocalizes with TLN1 at membrane ruffles Alternative splicing: named isoforms=2

General

cell surface receptor glycoprotein lectin

Properties

SIZE: MW = 43 kD entity length = 382 aa COMPARTMENT: plasma membrane MOTIF: signal sequence {1-21} C-type lectin {45-185} MOTIF: cysteine residue {C71} MODIFICATION: cysteine residue {C184} N-glycosylation site {N117} cysteine residue {C150} MODIFICATION: cysteine residue {C176} cysteine residue {C176} MODIFICATION: cysteine residue {C150} cysteine residue {C184} MODIFICATION: cysteine residue {C71} transmembrane domain {236-256} NF2 interactions {330-374} TLN1 interaction {337-382} MOTIF: E-S-G-X-V {340-344} E-S-G-X-V {350-354} N-X-I-Y {356-359} E-S-G-X-V {371-375} N-X-I-Y {377-380}

Database Correlations

UniProt Q6UX15 Pfam PF00059

References

UniProt :accession Q6UX15