latent-transforming growth factor beta-binding protein 4 (LTBP-4, LTBP4)

Function: - may be involved in assembly, secretion & targeting of TGFB1 to sites at which it is stored &/or activated - may play role in controlling & directing the activity of TGFB1 - may have a structural role in the extra cellular matrix (ECM) - forms part of the large latent TGF-beta precursor complex; removal is essential for activation of complex - interacts with LTBP1 & TGFB1 - binds to FBN1 - contains hydroxylated asparagine residues (putative) Structure: - belongs to the LTBP family - contains 16 EGF-like domains - contains 4 TGFBP (TGF-beta binding protein) repeats Compartment: - secreted, extracellular space, extracellular matrix Alternative splicing: named isoforms=4 Expression: - expressed in heart, skeletal muscle, pancreas, uterus, & small intestine > placenta & lung > fetal brain, liver, heart, spleen & thymus

General

glycoprotein secreted protein

Properties

SIZE: entity length = 1624 aa MW = 173 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-27} EGF domain {149-181} MOTIF: cysteine residue {C153} MODIFICATION: cysteine residue {C163} cysteine residue {C157} MODIFICATION: cysteine residue {C169} cysteine residue {C163} MODIFICATION: cysteine residue {C153} cysteine residue {C169} MODIFICATION: cysteine residue {C157} cysteine residue {C171} MODIFICATION: cysteine residue {C180} cysteine residue {C180} MODIFICATION: cysteine residue {C171} TGFBP {296-339} N-glycosylation site {N352} EGF domain {357-397} MOTIF: cysteine residue {C361} MODIFICATION: cysteine residue {C372} cysteine residue {C367} MODIFICATION: cysteine residue {C381} cysteine residue {C372} MODIFICATION: cysteine residue {C361} cysteine residue {C381} MODIFICATION: cysteine residue {C367} cysteine residue {C383} MODIFICATION: cysteine residue {C396} cysteine residue {C396} MODIFICATION: cysteine residue {C383} TGFBP {416-458} MOTIF: N-glycosylation site {N425} proline-rich region SITE: 478-565 MOTIF: proline residue (SEVERAL) EGF domain {545-586} cysteine-rich region {549-1118} MOTIF: cysteine residue {C549} MODIFICATION: cysteine residue {C561} cysteine residue {C556} MODIFICATION: cysteine residue {C570} cysteine residue {C561} MODIFICATION: cysteine residue {C549} cysteine residue {C570} MODIFICATION: cysteine residue {C556} cysteine residue {C572} MODIFICATION: cysteine residue {C585} cysteine residue {C585} MODIFICATION: cysteine residue {C572} EGF domain {587-628} cysteine residue {C591} MODIFICATION: cysteine residue {C603} cysteine residue {C598} MODIFICATION: cysteine residue {C612} cysteine residue {C603} MODIFICATION: cysteine residue {C591} cysteine residue {C612} MODIFICATION: cysteine residue {C598} cysteine residue {C614} MODIFICATION: cysteine residue {C627} cysteine residue {C627} MODIFICATION: cysteine residue {C614} EGF domain {629-670} cysteine residue {C633} MODIFICATION: cysteine residue {C645} cysteine residue {C640} MODIFICATION: cysteine residue {C654} cysteine residue {C645} MODIFICATION: cysteine residue {C633} cysteine residue {C654} MODIFICATION: cysteine residue {C640} cysteine residue {C656} MODIFICATION: cysteine residue {C669} cysteine residue {C669} MODIFICATION: cysteine residue {C656} EGF domain {671-708} cysteine residue {C675} MODIFICATION: cysteine residue {C687} cysteine residue {C682} MODIFICATION: cysteine residue {C696} cysteine residue {C687} MODIFICATION: cysteine residue {C675} cysteine residue {C696} MODIFICATION: cysteine residue {C682} cysteine residue {C698} MODIFICATION: cysteine residue {C707} cysteine residue {C707} MODIFICATION: cysteine residue {C698} EGF domain {710-751} cysteine residue {C714} MODIFICATION: cysteine residue {C726} cysteine residue {C721} MODIFICATION: cysteine residue {C735} cysteine residue {C726} MODIFICATION: cysteine residue {C714} cysteine residue {C735} MODIFICATION: cysteine residue {C721} cysteine residue {C737} MODIFICATION: cysteine residue {C750} cysteine residue {C750} MODIFICATION: cysteine residue {C737} EGF domain {752-793} cysteine residue {C756} MODIFICATION: cysteine residue {C768} cysteine residue {C763} MODIFICATION: cysteine residue {C777} cysteine residue {C768} MODIFICATION: cysteine residue {C756} cysteine residue {C777} MODIFICATION: cysteine residue {C763} cysteine residue {C779} MODIFICATION: cysteine residue {C792} cysteine residue {C792} MODIFICATION: cysteine residue {C779} EGF domain {834-877} cysteine residue {C838} MODIFICATION: cysteine residue {C851} cysteine residue {C845} MODIFICATION: cysteine residue {C860} cysteine residue {C851} MODIFICATION: cysteine residue {C838} cysteine residue {C860} MODIFICATION: cysteine residue {C845} cysteine residue {C862} MODIFICATION: cysteine residue {C876} cysteine residue {C876} MODIFICATION: cysteine residue {C862} EGF domain {878-919} cysteine residue {C882} MODIFICATION: cysteine residue {C894} cysteine residue {C888} MODIFICATION: cysteine residue {C903} cysteine residue {C894} MODIFICATION: cysteine residue {C882} cysteine residue {C903} MODIFICATION: cysteine residue {C888} cysteine residue {C905} MODIFICATION: cysteine residue {C918} cysteine residue {C918} MODIFICATION: cysteine residue {C905} EGF domain {920-960} cysteine residue {C924} MODIFICATION: cysteine residue {C935} cysteine residue {C930} MODIFICATION: cysteine residue {C944} cysteine residue {C935} MODIFICATION: cysteine residue {C924} cysteine residue {C944} MODIFICATION: cysteine residue {C930} cysteine residue {C946} MODIFICATION: cysteine residue {C959} cysteine residue {C959} MODIFICATION: cysteine residue {C946} EGF domain {1049-1090} cysteine residue {C1053} MODIFICATION: cysteine residue {C1065} N-glycosylation site {N1055} cysteine residue {C1059} MODIFICATION: cysteine residue {C1074} cysteine residue {C1065} MODIFICATION: cysteine residue {C1053} cysteine residue {C1074} MODIFICATION: cysteine residue {C1059} cysteine residue {C1076} MODIFICATION: cysteine residue {C1089} cysteine residue {C1089} MODIFICATION: cysteine residue {C1076} proline-rich region SITE: 1119-1175 MOTIF: proline residue (SEVERAL) TGFBP {1191-1234} MOTIF: N-glycosylation site {N1200} EGF domain {1253-1295} MOTIF: cysteine residue {C1257} MODIFICATION: cysteine residue {C1270} cysteine residue {C1265} MODIFICATION: cysteine residue {C1279} cysteine residue {C1270} MODIFICATION: cysteine residue {C1257} cysteine residue {C1279} MODIFICATION: cysteine residue {C1265} cysteine residue {C1281} MODIFICATION: cysteine residue {C1294} cysteine residue {C1294} MODIFICATION: cysteine residue {C1281} EGF domain {1296-1337} MOTIF: cysteine residue {C1300} MODIFICATION: cysteine residue {C1312} cysteine residue {C1307} MODIFICATION: cysteine residue {C1321} cysteine residue {C1312} MODIFICATION: cysteine residue {C1300} cysteine residue {C1321} MODIFICATION: cysteine residue {C1307} cysteine residue {C1323} MODIFICATION: cysteine residue {C1336} cysteine residue {C1336} MODIFICATION: cysteine residue {C1323} N-glycosylation site {N1339} TGFBP {1359-1401} proline-rich region SITE: 1407-1492 MOTIF: proline residue (SEVERAL) EGF domain {1533-1573} MOTIF: cysteine residue {C1537} MODIFICATION: cysteine residue {C1548} cysteine residue {C1543} MODIFICATION: cysteine residue {C1557} cysteine residue {C1548} MODIFICATION: cysteine residue {C1537} cysteine residue {C1557} MODIFICATION: cysteine residue {C1543} cysteine residue {C1559} MODIFICATION: cysteine residue {C1572} cysteine residue {C1572} MODIFICATION: cysteine residue {C1559} EGF domain {1574-1618} MOTIF: cysteine residue {C1578} MODIFICATION: cysteine residue {C1593} cysteine residue {C1588} MODIFICATION: cysteine residue {C1602} cysteine residue {C1593} MODIFICATION: cysteine residue {C1578} cysteine residue {C1602} MODIFICATION: cysteine residue {C1588} cysteine residue {C1604} MODIFICATION: cysteine residue {C1617} cysteine residue {C1617} MODIFICATION: cysteine residue {C1604}

Database Correlations

OMIM 604710 UniProt Q8N2S1 PFAM correlations

References

UniProt :accession Q8N2S1