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large neutral amino acids transporter small subunit 4 (L-type amino L-acid transporter 4, solute carrier family 43 member 2, SLC43A2, LAT4, PP7664)
Function:
- Na+, Cl-, pH-independent high affinity transport of large neutral amino acids
Structure:
- glycosylated (putative)
- belongs to the SLC43A transporter (TC 2.A.1.44) family
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- detected in several tissues
- higher expression in placenta, kidney & peripheral blood leukocytes
- in kidney, detected in epithelial cells of the distal tubule & collecting duct
- in the intestine, expressed mainly in crypt cells of the intestinal microvilli & epithelial cells in the base of the villus
General
amino acid transport protein
glycoprotein
phosphoprotein
solute carrier family 43 (SLC43, SLC43A)
Properties
SIZE: entity length = 569 aa
MW = 63 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
transmembrane domain {TM4}
transmembrane domain {TM5}
transmembrane domain {TM6}
transmembrane domain {TM7}
transmembrane domain {TM8}
transmembrane domain {TM9}
transmembrane domain {TM10}
transmembrane domain {TM11}
transmembrane domain {TM12}
transmembrane domain {20-40}
N-glycosylation site {N55}
N-glycosylation site {N58}
transmembrane domain {90-110}
transmembrane domain {120-140}
cytoplasmic domain {N-TERMINAL}
exoplasmic loop
LOOP#: 1
exoplasmic loop
LOOP#: 3
exoplasmic loop
LOOP#: 4
exoplasmic loop
LOOP#: 5
exoplasmic loop
LOOP#: 6
transmembrane domain {143-163}
transmembrane domain {177-197}
transmembrane domain {203-223}
Ser phosphorylation site {S274}
transmembrane domain {323-345}
transmembrane domain {365-385}
lysine-rich region {409-413}
MOTIF: lysine residue (SEVERAL)
cytoplasmic domain {C-TERMINAL}
transmembrane domain {435-455}
transmembrane domain {462-482}
transmembrane domain {490-510}
transmembrane domain {516-536}
N-glycosylation site {N560}
Database Correlations
UniProt Q8N370
Pfam PF07690
References
UniProt :accession Q8N370