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LanC-like protein 1; 40 kD erythrocyte membrane protein; p40 (LANCL1, GPR69A)
Function:
- may play a role in EPS8 signaling
- binds glutathione
- interacts with the C-terminal of STOM
- interacts with the EPS8 SH3 domain
- interaction with EPS8 is inhibited by glutathione binding
Structure:
- the N-terminus is blocked
- belongs to the LanC-like protein family
Compartment:
- cytoplasm
- membrane, peripheral membrane
- nucleus
Expression:
- ubiquitous
- strongly expressed in brain, spinal cord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary & testis
- detected in erythrocytes, brain, kidney, testis, ovary, heart, lung, placenta & spleen (at protein level)
Pathology:
- detected at the surface of Maurer's clefts in malaria- infected erythrocytes at late stages of parasite development
- interacts with P falciparum SBP1
Note:
- originally thought to be a G-protein coupled receptor [3]
General
glycoprotein
LanC-like protein; lanthionine-synthetase component C-like 1 (LanC-LIKE, LANCL)
Properties
SIZE: entity length = 399 aa
MW = 45 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
glycosylation site
Zn+2-binding site
SITE: 276-276
binding site
SITE: 317-317
FOR-BINDING-OF: Glutathione
Zn+2-binding site
SITE: 322-322
Zn+2-binding site
SITE: 323-323
Glutathione binding {364-367}
Database Correlations
OMIM 604155
UniProt O43813
Pfam PF05147
Entrez Gene 10314
Kegg hsa:10314
References
- UniProt :accession O43813
- OMIM :accession 604155
- PMID: 9512664