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lamin-B
Function:
- lamins are components of the nuclear lamina (see lamin)
- lamin A & lamin C filaments cross-link into an orthogonal lattice (nuclear lamina), which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor
- increased phosphorylation of the lamins occurs before nuclear envelope disintegration & probably plays a role in regulating lamin associations
Interactions
molecular events
Specific
lamin-B1 (LMNB1 LMN2 LMNB)
lamin-B2 (LMNB2 LMN2)
General
lamin or nuclear lamin
Properties
COMPARTMENT: nuclear membrane
MOTIF: O-glycosylation site {N-TERMINAL}
rod-like {central-region}
MOTIF: alpha helix
coiled coil
S/T phosphorylation site
nuclear translocation signal
CaaX motif
SITE: C-TERMINUS
EFFECTOR-BOUND: farnesyl
References
- Holtz D et al
The CaaX motif of lamin A functions in conjunction with
the nuclear localization signal to target assembly to the
nuclear envelope.
Cell 59:969 1989
PMID: 2557160
- Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL.
Protein farnesyltransferase and geranylgeranyltransferase share
a common alpha subunit.
Cell. 1991 May 3;65(3):429-34.
PMID: 2018975111
Component-of
molecular complex