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laminin subunit alpha-2; laminin M chain; merosin heavy chain (LAMA2, LAMM)
Function:
- see laminin
- subunit of laminin-2 (merosin) & laminin-4 (S-merosin)
Structure:
- alpha-helical domains I & II are thought to interact with other laminin chains to form a coiled coil structure
- domains VI, IV & G are globular
- contains 17 laminin EGF-like domains
- contains 5 laminin G-like domains
- contains 2 laminin IV type A domains
- contains 1 laminin N-terminal domain
Compartment:
- secreted, extracellular matrix, basement membrane
- major component of basement membrane
Expression:
- expressed in placenta, striated muscle, peripheral nerve, cardiac muscle, pancreas, lung, spleen, kidney, adrenal gland, skin, testis, meninges, choroid plexus, & some other regions of the brain
- not expressed in liver, thymus & bone
Pathology:
- defects in LAMA2 are the cause of merosin-deficient congenital muscular dystrophy type 1A
Laboratory:
- laminin alpha 2 in tissue
General
cell adhesion protein
glycoprotein
laminin-alpha (laminin A)
matrix protein
protein subunit
Properties
SIZE: entity length = 3110 aa
MW = 343 kD
MOTIF: signal sequence {1-22}
Laminin N-terminal {35-286}
MOTIF: N-glycosylation site {N55}
N-glycosylation site {N89}
EGF domain {287-343}
MOTIF: cysteine residue {C287}
MODIFICATION: cysteine residue {C296}
cysteine residue {C289}
MODIFICATION: cysteine residue {C307}
cysteine residue {C296}
MODIFICATION: cysteine residue {C287}
N-glycosylation site {N303}
cysteine residue {C307}
MODIFICATION: cysteine residue {C289}
cysteine residue {C309}
MODIFICATION: cysteine residue {C318}
cysteine residue {C318}
MODIFICATION: cysteine residue {C309}
cysteine residue {C321}
MODIFICATION: cysteine residue {C341}
cysteine residue {C341}
MODIFICATION: cysteine residue {C321}
EGF domain {344-413}
MOTIF: cysteine residue {C344}
MODIFICATION: cysteine residue {C353}
cysteine residue {C346}
MODIFICATION: cysteine residue {C378}
cysteine residue {C353}
MODIFICATION: cysteine residue {C344}
N-glycosylation site {N363}
cysteine residue {C378}
MODIFICATION: cysteine residue {C346}
N-glycosylation site {N380}
cysteine residue {C381}
MODIFICATION: cysteine residue {C390}
cysteine residue {C390}
MODIFICATION: cysteine residue {C381}
cysteine residue {C393}
MODIFICATION: cysteine residue {C411}
cysteine residue {C411}
MODIFICATION: cysteine residue {C393}
EGF domain {414-468}
MOTIF: cysteine residue {C414}
MODIFICATION: cysteine residue {C426}
cysteine residue {C416}
MODIFICATION: cysteine residue {C442}
cysteine residue {C426}
MODIFICATION: cysteine residue {C414}
cysteine residue {C442}
MODIFICATION: cysteine residue {C416}
cysteine residue {C444}
MODIFICATION: cysteine residue {C453}
cysteine residue {C453}
MODIFICATION: cysteine residue {C444}
cysteine residue {C456}
MODIFICATION: cysteine residue {C466}
cysteine residue {C466}
MODIFICATION: cysteine residue {C456}
EGF domain {469-517}
MOTIF: cysteine residue {C469}
MODIFICATION: cysteine residue {C482}
N-glycosylation site {N470}
cysteine residue {C471}
MODIFICATION: cysteine residue {C486}
cysteine residue {C482}
MODIFICATION: cysteine residue {C469}
cysteine residue {C486}
MODIFICATION: cysteine residue {C471}
cysteine residue {C488}
MODIFICATION: cysteine residue {C497}
cysteine residue {C497}
MODIFICATION: cysteine residue {C488}
cysteine residue {C500}
MODIFICATION: cysteine residue {C515}
cysteine residue {C515}
MODIFICATION: cysteine residue {C500}
EGF domain {518-527}
Laminin IV type A 1 {531-723}
EGF domain {724-756}
MOTIF: N-glycosylation site {N746}
EGF domain {757-806}
MOTIF: cysteine residue {C757}
MODIFICATION: cysteine residue {C766}
cysteine residue {C759}
MODIFICATION: cysteine residue {C773}
cysteine residue {C766}
MODIFICATION: cysteine residue {C757}
cysteine residue {C773}
MODIFICATION: cysteine residue {C759}
cysteine residue {C776}
MODIFICATION: cysteine residue {C785}
cysteine residue {C785}
MODIFICATION: cysteine residue {C776}
cysteine residue {C788}
MODIFICATION: cysteine residue {C804}
cysteine residue {C804}
MODIFICATION: cysteine residue {C788}
EGF domain {807-864}
MOTIF: cysteine residue {C807}
MODIFICATION: cysteine residue {C822}
cysteine residue {C809}
MODIFICATION: cysteine residue {C832}
cysteine residue {C822}
MODIFICATION: cysteine residue {C807}
cysteine residue {C832}
MODIFICATION: cysteine residue {C809}
cysteine residue {C835}
MODIFICATION: cysteine residue {C844}
cysteine residue {C844}
MODIFICATION: cysteine residue {C835}
cysteine residue {C847}
MODIFICATION: cysteine residue {C862}
cysteine residue {C862}
MODIFICATION: cysteine residue {C847}
EGF domain {865-917}
MOTIF: cysteine residue {C865}
MODIFICATION: cysteine residue {C879}
cysteine residue {C867}
MODIFICATION: cysteine residue {C886}
cysteine residue {C879}
MODIFICATION: cysteine residue {C865}
cysteine residue {C886}
MODIFICATION: cysteine residue {C867}
cysteine residue {C889}
MODIFICATION: cysteine residue {C898}
cysteine residue {C898}
MODIFICATION: cysteine residue {C889}
cysteine residue {C901}
MODIFICATION: cysteine residue {C915}
cysteine residue {C915}
MODIFICATION: cysteine residue {C901}
EGF domain {918-966}
MOTIF: cysteine residue {C918}
MODIFICATION: cysteine residue {C930}
cysteine residue {C920}
MODIFICATION: cysteine residue {C937}
cysteine residue {C930}
MODIFICATION: cysteine residue {C918}
cysteine residue {C937}
MODIFICATION: cysteine residue {C920}
cysteine residue {C939}
MODIFICATION: cysteine residue {C948}
cysteine residue {C948}
MODIFICATION: cysteine residue {C939}
cysteine residue {C951}
MODIFICATION: cysteine residue {C964}
cysteine residue {C964}
MODIFICATION: cysteine residue {C951}
EGF domain {967-1013}
MOTIF: cysteine residue {C967}
MODIFICATION: cysteine residue {C979}
cysteine residue {C969}
MODIFICATION: cysteine residue {C985}
cysteine residue {C979}
MODIFICATION: cysteine residue {C967}
cysteine residue {C985}
MODIFICATION: cysteine residue {C969}
cysteine residue {C987}
MODIFICATION: cysteine residue {C996}
cysteine residue {C996}
MODIFICATION: cysteine residue {C987}
cysteine residue {C999}
MODIFICATION: cysteine residue {C1011}
cysteine residue {C1011}
MODIFICATION: cysteine residue {C999}
EGF domain {1014-1059}
MOTIF: cysteine residue {C1014}
MODIFICATION: cysteine residue {C1023}
cysteine residue {C1016}
MODIFICATION: cysteine residue {C1030}
cysteine residue {C1023}
MODIFICATION: cysteine residue {C1014}
cysteine residue {C1030}
MODIFICATION: cysteine residue {C1016}
cysteine residue {C1032}
MODIFICATION: cysteine residue {C1041}
cysteine residue {C1041}
MODIFICATION: cysteine residue {C1032}
cysteine residue {C1044}
MODIFICATION: cysteine residue {C1057}
cysteine residue {C1057}
MODIFICATION: cysteine residue {C1044}
EGF domain {1060-1105}
MOTIF: cysteine residue {C1060}
MODIFICATION: cysteine residue {C1072}
N-glycosylation site {N1061}
cysteine residue {C1062}
MODIFICATION: cysteine residue {C1079}
cysteine residue {C1072}
MODIFICATION: cysteine residue {C1060}
cysteine residue {C1079}
MODIFICATION: cysteine residue {C1062}
cysteine residue {C1081}
MODIFICATION: cysteine residue {C1090}
cysteine residue {C1090}
MODIFICATION: cysteine residue {C1081}
cysteine residue {C1093}
MODIFICATION: cysteine residue {C1103}
cysteine residue {C1103}
MODIFICATION: cysteine residue {C1093}
EGF domain {1106-1165}
MOTIF: cysteine residue {C1106}
MODIFICATION: cysteine residue {C1118}
cysteine residue {C1108}
MODIFICATION: cysteine residue {C1134}
cysteine residue {C1118}
MODIFICATION: cysteine residue {C1106}
cysteine residue {C1134}
MODIFICATION: cysteine residue {C1108}
cysteine residue {C1136}
MODIFICATION: cysteine residue {C1145}
cysteine residue {C1145}
MODIFICATION: cysteine residue {C1136}
cysteine residue {C1148}
MODIFICATION: cysteine residue {C1163}
cysteine residue {C1163}
MODIFICATION: cysteine residue {C1148}
EGF domain {1166-1175}
Laminin IV type A 2 {1176-1379}
EGF domain {1380-1419}
EGF domain {1420-1468}
MOTIF: cysteine residue {C1420}
MODIFICATION: cysteine residue {C1429}
cysteine residue {C1422}
MODIFICATION: cysteine residue {C1436}
cysteine residue {C1429}
MODIFICATION: cysteine residue {C1420}
cysteine residue {C1436}
MODIFICATION: cysteine residue {C1422}
cysteine residue {C1439}
MODIFICATION: cysteine residue {C1448}
cysteine residue {C1448}
MODIFICATION: cysteine residue {C1439}
cysteine residue {C1451}
MODIFICATION: cysteine residue {C1466}
cysteine residue {C1466}
MODIFICATION: cysteine residue {C1451}
EGF domain {1469-1526}
MOTIF: cysteine residue {C1469}
MODIFICATION: cysteine residue {C1484}
cysteine residue {C1471}
MODIFICATION: cysteine residue {C1494}
cysteine residue {C1484}
MODIFICATION: cysteine residue {C1469}
cysteine residue {C1494}
MODIFICATION: cysteine residue {C1471}
cysteine residue {C1497}
MODIFICATION: cysteine residue {C1506}
cysteine residue {C1506}
MODIFICATION: cysteine residue {C1497}
cysteine residue {C1509}
MODIFICATION: cysteine residue {C1524}
cysteine residue {C1524}
MODIFICATION: cysteine residue {C1509}
EGF domain {1527-1573}
MOTIF: cysteine residue {C1527}
MODIFICATION: cysteine residue {C1539}
cysteine residue {C1529}
MODIFICATION: cysteine residue {C1546}
cysteine residue {C1539}
MODIFICATION: cysteine residue {C1527}
cysteine residue {C1546}
MODIFICATION: cysteine residue {C1529}
cysteine residue {C1548}
MODIFICATION: cysteine residue {C1557}
cysteine residue {C1557}
MODIFICATION: cysteine residue {C1548}
cysteine residue {C1560}
MODIFICATION: cysteine residue {C1571}
cysteine residue {C1571}
MODIFICATION: cysteine residue {C1560}
Domain II and I {1574-2144}
MOTIF: cysteine residue {C1574}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C1578}
MODIFICATION: cysteine residue {C-INTERCHAIN}
N-glycosylation site {N1597}
N-glycosylation site {N1614}
coiled coil {1630-2150}
MOTIF: N-glycosylation site {N1700}
N-glycosylation site {N1810}
N-glycosylation site {N1901}
N-glycosylation site {N1916}
N-glycosylation site {N1920}
N-glycosylation site {N2017}
N-glycosylation site {N2028}
N-glycosylation site {N2045}
N-glycosylation site {N2126}
Laminin G-like 1 {2145-2328}
MOTIF: N-glycosylation site {N2240}
cysteine residue {C2302}
MODIFICATION: cysteine residue {C2328}
cysteine residue {C2328}
MODIFICATION: cysteine residue {C2302}
Laminin G-like 2 {2340-2521}
MOTIF: N-glycosylation site {N2360}
N-glycosylation site {N2435}
N-glycosylation site {N2478}
cysteine residue {C2495}
MODIFICATION: cysteine residue {C2521}
cysteine residue {C2521}
MODIFICATION: cysteine residue {C2495}
Laminin G-like 3 {2526-2710}
MOTIF: N-glycosylation site {N2551}
N-glycosylation site {N2558}
N-glycosylation site {N2648}
cysteine residue {C2683}
MODIFICATION: cysteine residue {C2710}
cysteine residue {C2710}
MODIFICATION: cysteine residue {C2683}
Laminin G-like 4 {2763-2934}
MOTIF: N-glycosylation site {N2868}
N-glycosylation site {N2893}
cysteine residue {C2909}
MODIFICATION: cysteine residue {C2934}
cysteine residue {C2934}
MODIFICATION: cysteine residue {C2909}
Laminin G-like 5 {2939-3110}
Database Correlations
OMIM correlations
UniProt P24043
PFAM correlations
Entrez Gene 3908
Kegg hsa:3908
References
- UniProt :accession P24043
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=LAMA2
Component-of
laminin-4 (S-merosin)