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lamin or nuclear lamin
Function:
- lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope & may also interact with chromatin
- structural integrity of lamins & the nuclear lamina is cell cycle dependent, with disintegration of the nuclear envelope in prophase & reformation in telophase
- increased phosphorylation of the lamins occurs before nuclear envelope disintegration & probably plays a role in regulating lamin associations
Laboratory:
- lamin Ab in serum
Interactions
molecular events
Specific
lamin-A/C; 70 kD lamin; renal carcinoma antigen NY-REN-32 (LMNA, LMN1)
lamin-B
General
intermediate filament protein
nuclear membrane protein
oligomerizing protein
phosphoprotein
prenyl protein
Properties
COMPARTMENT: nuclear membrane
MOTIF: O-glycosylation site {N-TERMINAL}
rod-like {central-region}
MOTIF: alpha helix
coiled coil
S/T phosphorylation site
nuclear translocation signal
CaaX motif
SITE: C-TERMINUS
EFFECTOR-BOUND: farnesyl
References
- Holtz D et al
The CaaX motif of lamin A functions in conjunction with
the nuclear localization signal to target assembly to the
nuclear envelope.
Cell 59:969 1989
PMID: 2557160
- Alperts et al Molecular Biology of the Cell, Garland
Publishing, New York, NY 1989 pg 662