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LAG1 longevity assurance homolog 6; ceramide synthase 6 (CERS6, LASS6)
Function:
- role in sphingolipid synthesis or its regulation
- glycosylation on Asn-18 is not necessary for function
Structure:
- N-glycosylated
- contains 1 homeobox DNA-binding domain
- contains 1 TLC (TRAM/LAG1/CLN8) domain
Compartment:
- nuclear membrane
- endoplasmic reticulum membrane
- multi-pass membrane protein (putative)
Related
Lag1 (longevity assurance gene 1) transcription factor
General
glycoprotein
LAG1 longevity assurance homolog
Properties
SIZE: entity length = 384 aa
MW = 45 kD
COMPARTMENT: cell nucleus
endoplasmic reticulum
MOTIF: exoplasmic domain {1-34}
MOTIF: N-glycosylation site {N18}
transmembrane domain {35-55}
cytoplasmic loop {56-177}
MOTIF: homeodomain
SITE: 66-127
transmembrane domain {178-198}
exoplasmic loop {199-204}
transmembrane domain {205-225}
cytoplasmic loop {226-262}
transmembrane domain {263-283}
exoplasmic loop {284-302}
transmembrane domain {303-323}
cytoplasmic domain {324-384}
Database Correlations
UniProt Q6ZMG9
PFAM correlations
Entrez Gene 253782
Kegg hsa:253782
References
UniProt :accession Q6ZMG9