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LAG1 longevity assurance homolog 5; ceramide synthase 5 (CERS5, LASS5)
Function:
- ceramide synthesis
- when overexpressed in cells, LASS5 is involved in production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl- (C16) ceramide) independent of fumonisin B1
Structure:
- contains 1 homeobox DNA-binding domain
- contains 1 TLC (TRAM/LAG1/CLN8) domain
Compartment:
- nuclear membrane
- endoplasmic reticulum membrane
- multi-pass membrane protein (putative)
Related
Lag1 (longevity assurance gene 1) transcription factor
General
glycoprotein
LAG1 longevity assurance homolog
phosphoprotein
transmembrane 6e protein
Properties
SIZE: entity length = 392 aa
MW = 46 kD
COMPARTMENT: cell nucleus
endoplasmic reticulum
MOTIF: exoplasmic domain {1-46}
MOTIF: N-glycosylation site {N26}
transmembrane domain {47-67}
cytoplasmic loop {68-147}
MOTIF: homeodomain
SITE: 75-136
transmembrane domain {148-168}
exoplasmic loop {169-182}
transmembrane domain {183-203}
cytoplasmic loop {204-213}
transmembrane domain {214-234}
exoplasmic loop {235-271}
transmembrane domain {272-292}
cytoplasmic loop {293-310}
transmembrane domain {311-331}
exoplasmic domain {332-392}
MOTIF: Ser phosphorylation site {S350}
Ser phosphorylation site {S354}
Ser phosphorylation site {S355}
Ser phosphorylation site {S356}
Database Correlations
UniProt Q8N5B7
PFAM correlations
Entrez Gene 91012
Kegg hsa:91012
References
UniProt :accession Q8N5B7