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ceramide synthase 2; cerS2; LAG1 longevity assurance homolog 2; SP260; tumor metastasis-suppressor gene 1 protein (CERS2 LASS2 TMSG1)
Function:
- suppresses growth of cancer cells
- may be involved in sphingolipid synthesis
- interacts with ATP6V0C, ASGR1, ASGR2 & SLC22A1/OCT1
- interacts with ELOV1, HSD17B12 & TECR
Structure:
- contains 1 homeobox DNA-binding domain
- contains 1 TLC (TRAM/LAG1/CLN8) domain
Compartment:
- nuclear membrane
- endoplasmic reticulum membrane
- multi-pass membrane protein (putative)
Expression:
- expressed in kidney, liver, brain, heart, placenta & lung
Related
metastasis
General
glycoprotein
nuclear protein
phosphoprotein
transmembrane 6e protein
Properties
SIZE: entity length = 380 aa
MW = 45 kD
COMPARTMENT: cell nucleus
endoplasmic reticulum
MOTIF: exoplasmic domain {1-40}
MOTIF: N-glycosylation site {N19}
transmembrane domain {41-61}
cytoplasmic loop {62-139}
MOTIF: homeodomain
SITE: 67-128
transmembrane domain {140-160}
exoplasmic loop {161-180}
transmembrane domain {181-201}
cytoplasmic loop {202-208}
transmembrane domain {209-229}
exoplasmic loop {230-263}
transmembrane domain {264-284}
cytoplasmic loop {285-303}
transmembrane domain {304-324}
exoplasmic domain {325-380}
MOTIF: Ser phosphorylation site {S341}
Thr phosphorylation site {T346}
Ser phosphorylation site {S348}
Ser phosphorylation site {S349}
Database Correlations
OMIM 606920
UniProt Q96G23
PFAM correlations
Entrez Gene 29956
Kegg hsa:29956
References
UniProt :accession Q96G23